Receptor metabotrópico de glutamato 5

Este artigo cobrirá o tópico Receptor metabotrópico de glutamato 5 detalhada e exaustivamente. Serão analisados ​​diferentes aspectos relacionados a Receptor metabotrópico de glutamato 5, desde sua origem até seu impacto hoje. Serão discutidas as diferentes posições e opiniões sobre o assunto, bem como as implicações que Receptor metabotrópico de glutamato 5 tem nas diversas áreas da vida. Através deste artigo, procuramos proporcionar ao leitor uma visão completa e objetiva de Receptor metabotrópico de glutamato 5, permitindo-lhe compreender a fundo a sua importância e as suas possíveis implicações no mundo atual.

Glutamate metabotropic receptor 5
Identificadores
Nomes alternativos
IDs externosGeneCards:
Wikidata
Ver/Editar Humano

O receptor metabotrópico de glutamato 5 é uma proteína que em seres humanos é codificada pelo gene GRM5.[1][2][3] Os receptores metabotrópicos de glutamato são uma família de receptores acoplados à proteína G.

Antagonistas

  • Mavoglurant
  • Remeglurant
  • LY-344,545

Referências

  1. ↑ Chad J. Swanson, Mark Bures, Michael P. Johnson, Anni-Maija Linden, James A. Monn & Darryle D. Schoepp. «Metabotropic glutamate receptors as novel targets for anxiety and stress disorders» (em inglês). fevereiro de 2005. Consultado em 1 de julho de 2010 
  2. ↑ Minakami R, Katsuki F, Yamamoto T, Nakamura K, Sugiyama H (1994). «Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5». Biochem Biophys Res Commun. 199 (3): 1136–43. PMID 7908515. doi:10.1006/bbrc.1994.1349 
  3. ↑ «Entrez Gene: GRM5 glutamate receptor, metabotropic 5» 

Bibliografia

  • Minakami R, Katsuki F, Sugiyama H (1993). «A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon.». Biochem. Biophys. Res. Commun. 194 (2): 622–7. PMID 7688218. doi:10.1006/bbrc.1993.1866 
  • Daggett LP, Sacaan AI, Akong M; et al. (1996). «Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5.». Neuropharmacology. 34 (8): 871–86. PMID 8532169. doi:10.1016/0028-3908(95)00085-K 
  • Brakeman PR, Lanahan AA, O'Brien R; et al. (1997). «Homer: a protein that selectively binds metabotropic glutamate receptors.». Nature. 386 (6622): 284–8. PMID 9069287. doi:10.1038/386284a0 
  • Minakami R, Jinnai N, Sugiyama H (1997). «Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro.». J. Biol. Chem. 272 (32): 20291–8. PMID 9242710. doi:10.1074/jbc.272.32.20291 
  • Snow BE, Hall RA, Krumins AM; et al. (1998). «GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.». J. Biol. Chem. 273 (28): 17749–55. PMID 9651375. doi:10.1074/jbc.273.28.17749 
  • Xiao B, Tu JC, Petralia RS; et al. (1998). «Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.». Neuron. 21 (4): 707–16. PMID 9808458. doi:10.1016/S0896-6273(00)80588-7 
  • Enz R (2002). «The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.». FEBS Lett. 514 (2-3): 184–8. PMID 11943148. doi:10.1016/S0014-5793(02)02361-X 
  • Saugstad JA, Yang S, Pohl J; et al. (2002). «Interaction between metabotropic glutamate receptor 7 and alpha tubulin.». J. Neurochem. 80 (6): 980–8. PMID 11953448. doi:10.1046/j.0022-3042.2002.00778.x 
  • Nash MS, Schell MJ, Atkinson PJ; et al. (2002). «Determinants of metabotropic glutamate receptor-5-mediated Ca2+ and inositol 1,4,5-trisphosphate oscillation frequency. Receptor density versus agonist concentration.». J. Biol. Chem. 277 (39): 35947–60. PMID 12119301. doi:10.1074/jbc.M205622200 
  • Bates B, Xie Y, Taylor N; et al. (2003). «Characterization of mGluR5R, a novel, metabotropic glutamate receptor 5-related gene.». Brain Res. Mol. Brain Res. 109 (1-2): 18–33. PMID 12531512. doi:10.1016/S0169-328X(02)00458-8 
  • Malherbe P, Kew JN, Richards JG; et al. (2003). «Identification and characterization of a novel splice variant of the metabotropic glutamate receptor 5 gene in human hippocampus and cerebellum.». Brain Res. Mol. Brain Res. 109 (1-2): 168–78. PMID 12531526. doi:10.1016/S0169-328X(02)00557-0 
  • O'Malley KL, Jong YJ, Gonchar Y; et al. (2003). «Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons.». J. Biol. Chem. 278 (30): 28210–9. PMID 12736269. doi:10.1074/jbc.M300792200 
  • Corti C, Clarkson RW, Crepaldi L; et al. (2003). «Gene structure of the human metabotropic glutamate receptor 5 and functional analysis of its multiple promoters in neuroblastoma and astroglioma cells.». J. Biol. Chem. 278 (35): 33105–19. PMID 12783878. doi:10.1074/jbc.M212380200 
  • Aronica E, Gorter JA, Ijlst-Keizers H; et al. (2003). «Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins.». Eur. J. Neurosci. 17 (10): 2106–18. PMID 12786977. doi:10.1046/j.1460-9568.2003.02657.x 
  • Uchino M, Sakai N, Kashiwagi K; et al. (2004). «Isoform-specific phosphorylation of metabotropic glutamate receptor 5 by protein kinase C (PKC) blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKC.». J. Biol. Chem. 279 (3): 2254–61. PMID 14561742. doi:10.1074/jbc.M309894200 
  • Anneser JM, Ince PG, Shaw PJ, Borasio GD (2004). «Differential expression of mGluR5 in human lumbosacral motoneurons.». Neuroreport. 15 (2): 271–3. PMID 15076751. doi:10.1097/00001756-200402090-00012 
  • Pacheco R, Ciruela F, Casadó V; et al. (2004). «Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation.». J. Biol. Chem. 279 (32): 33352–8. PMID 15184389. doi:10.1074/jbc.M401761200 
  • Kim CH, Braud S, Isaac JT, Roche KW (2005). «Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on Serine 839 regulates Ca2+ oscillations.». J. Biol. Chem. 280 (27): 25409–15. PMID 15894802. doi:10.1074/jbc.M502644200 
  • Cabello N, Remelli R, Canela L; et al. (2007). «Actin-binding protein alpha-actinin-1 interacts with the metabotropic glutamate receptor type 5b and modulates the cell surface expression and function of the receptor.». J. Biol. Chem. 282 (16): 12143–53. PMID 17311919. doi:10.1074/jbc.M608880200